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KMID : 0356019930080010047
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Koean Jounral of Critical Care Medicine
1993 Volume.8 No. 1 p.47 ~ p.52
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Effects of Preanesthetic Administration of Cimetidine or Ranitidine on Postoperative Liver Function
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Abstract
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Aspiration of gastric contents into the tracheobronchial tree is a major cause of anesthesiarelated morbidity and mortality.
The pH of gastric contents less than 2.5 is generally considered the critical level for the development of pulmonary damage. Therefore, for the increase of gastric pH and the decrease of gastric volume preanesthetic administration of cimetidine
or
ranitidine is recommendable.
Cimetidine or ranitidine as premedicant was administered to ninety patients in ASA lass 1~3 scheduled for elective operation under general anesthesia at Yongsan hospital from November 1992 to March 1993. The liver functions were evaluated
preoperatively
and on the postoperative 3rd day.
@ES The results were as follows:
@EN 1) Pre- or postoperative SGOT, SGPT and alkaline phosphatase(ALP) showed no significant changes in cimetidine- or ranitidine-injected group with normal liver function and in cimetidine-injected group with abnormal liver function.
2) In the ranitidine-injected group with abnormal liver function SGOT, SGPT and ALP decreased significantly after operation(p<0.05).
Above results suggested that ranitidine is more effective than cimetidine as premedicant to the patient with abnormal liver function.
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